1344. Ridinilazole (RDZ) for Clostridium difficile Infection (CDI): Impact of Diagnostic Method on Outcomes From a Phase 2 Clinical Trial
نویسندگان
چکیده
منابع مشابه
Impact on toxin production and cell morphology in Clostridium difficile by ridinilazole (SMT19969), a novel treatment for C. difficile infection
OBJECTIVES Ridinilazole (SMT19969) is a narrow-spectrum, non-absorbable antimicrobial with activity against Clostridium difficile undergoing clinical trials. The purpose of this study was to assess the pharmacological activity of ridinilazole and assess the effects on cell morphology. METHODS Antibiotic killing curves were performed using the epidemic C. difficile ribotype 027 strain, R20291,...
متن کاملDoes empirical Clostridium difficile infection (CDI) therapy result in false-negative CDI diagnostic test results?
BACKGROUND Patients with suspected Clostridium difficile infection (CDI) often receive empirical therapy prior to collection of stool specimens for diagnostic testing. The likelihood that such empirical therapy might result in false-negative CDI test results is unknown. METHODS We conducted a prospective study of CDI patients to determine the time to conversion of CDI test results, including ...
متن کاملSusceptibility of Clostridium difficile isolates from a Phase 2 clinical trial of cadazolid and vancomycin in C. difficile infection
OBJECTIVES The aim of this study was to evaluate the susceptibilities of Clostridium difficile isolates to cadazolid, a novel antibiotic for the treatment of C. difficile infection. METHODS Ribotyping and susceptibilities were determined for C. difficile isolates from a multicentre, double-blind, Phase 2 study of oral cadazolid in patients with C. difficile infection (NCT01222702, ClinicalTri...
متن کاملNew advances in the treatment of Clostridium difficile infection (CDI)
Clostridium difficile infections (CDI) have increased in frequency throughout the world. In addition to an increase in frequency, recent CDI epidemics have been linked to a hypervirulent C. difficile strain resulting in greater severity of disease. Although most mild to moderate cases of CDI continue to respond to metronidazole or vancomycin, refractory and recurrent cases of CDI may require al...
متن کاملClostridium difficile infection in children – clinical, diagnostic and therapeutic aspects
Methods We present 4 cases of children admitted to the National Institute for Infectious Diseases “Prof. Dr. Matei Balş” in the last year with Clostridium difficile colitis; the children had ages between 2 and 12 years. Diagnosis of infection was based on the presence of three or more stools in a 24 hour period, isolation of the organism and detection of toxins A/B in a diarrheal stool specimen...
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2018
ISSN: 2328-8957
DOI: 10.1093/ofid/ofy210.1175